Influence
of CardioPhase on Hemodynamics and Rheology of Coronary Artery
Disease
Cui Huarong, Zhao Xiaoli, Zou
Xuefeng, Liu Sili, Ge Xingli, Zhang Xiulian, Chen Haoran
Cardiac Medical Department of the First Medical College, Xi’an
China
We studied 30 cases of coronary artery disease to determine
the influence of CardioPhase on four parameters of hemodynamics
(the forces generated by the heart and the motion of blood
through the cardiovascular system) and hemorheology (the study
of the properties and flow of blood, i.e. viscosity, arterial/venous
diameter, blood consistency and vasculature):
A. Cardiac
Performance
B. Vascular Function
C. Blood Viscosity
D. Microcirculation Function
The study included 18 men and
12 women with an average age of 56.8. All patients were diagnosed
with coronary artery disease and included 15 cases of angina
pectoris, 10 cases of cardiac dysrhythmia and 10 cases of
essential hypertension. Each patient was treated with CardioPhase,
three times per day, for a period of six weeks. None of the
study participants took any cardiovascular medicines during
the test period.
Results
Study results
revealed statistically significant positive improvements in
the following parameters of cardiac performance:
A.
Cardiac Performance
| Item |
Normal Value |
Pretherapy |
Post-Treatment
|
P |
PR |
Reduction in pulse rate |
70±10time/min |
71.17±1.987 |
68.6±1.947 |
<0.005 |
| SV |
Reduction in leaf chamber spray blood pressure |
80~90ml/L |
71.85±1.98 |
92.31±1.76 |
<0.05 |
SWI |
Reduction in myocardial oxygen consumption |
70~90gM/b/m2 |
68.78±1.872 |
82.035±1.192 |
<0.05 |
| CI |
Marked improvement in stroke volume |
3~7L/min/m2 |
2.841±0.227 |
3.757±0.159 |
<0.01 |
| VPE |
Marked improvement in cardiac impulse index |
1.8kg/b |
1.756±0.161 |
2.027±0.0635 |
<0.05 |
| HOV |
Marked improvement in cardiac index |
21.85~40.79ml/min |
41.48±1.923 |
39.63±1.771 |
<0.05 |
| EWK |
Leaf chamber validity pump rate |
0.28~0.30 |
0.2739±0.0073 |
0.2935±0.7739 |
<0.05 |
| VER |
Leaf chamber energy availability |
160~220dyn.s.cm2 |
230.26±7.50 |
1.883±7.49 |
<0.005 |
| CCP |
Coronary perfusion pressure |
6.65~9.31kPa |
6.507±0.663 |
8.037±0.534 |
<0.001 |
| CMBR |
Myocardium ratio of perfusion with consumption |
≥1 |
0.8307±0.0126 |
1.144±0.0123 |
<0.001 |
Table
1. CardioPhase’s influence on cardiac
performance. |
B.
Vascular Function
| Item |
Normal Value |
Pretherapy |
Post-Treatment
|
P |
PAP |
Pulmonary artery pressure |
2~4kPa |
4.670±0.1287 |
2.633±0.08436 |
<0.005 |
| PAR |
Pulmonary vascular resistance |
100~300dyn.s.cm2 |
303.87±43.64 |
164.206±26.56 |
<0.005 |
FEK |
Blood vessel elasticity flare factor |
0.35~0.55 |
0.2424±0.0263 |
0.407±0.053 |
<0.005 |
| TPR |
Total peripheral resistance |
800~1300 dyn.s.cm2 |
1569.5±128.908 |
1191.1±58.54 |
<0.005 |
| SPR |
Standard peripheral resistance |
900~1400 dyn.s.cm2 |
1565.2±120.146 |
1135.9±63.726 |
<0.005 |
Table
2. CardioPhase’s influence on blood vessel
function. |
C.
Blood Viscosity
| Item |
Normal Value |
Pretherapy |
Post-Treatment
|
P |
WB |
Whole blood viscosity – significant
reduction |
3~4mpa.s |
4.7501±0.0078 |
3.2723±0.1298 |
<0.05 |
| RB |
Reduced blood viscosity - significant reduction |
3~4mpa.s |
4.367±0.434 |
3.395±0.164 |
<0.01 |
Table
3. CardioPhase’s influence on blood viscosity. |
D.
Microcirculation Function
| Item |
Normal Value |
Pretherapy |
Post-Treatment
|
P |
MHR |
Microcirculation turnover rate |
0.04~0.08 |
0.06628±0.01937 |
0.0461±0.00202 |
<0.05 |
| MRT |
Microcirculation half-turnover time |
10~20s |
24.859±2.7204 |
18.257±1.064 |
<0.05 |
MST |
Microcirculation average stagnation time |
15~30s |
33.46±2.48 |
23.404±1.429 |
<0.02 |
Table
4. CardioPhase’s influence on circulation. |
Conclusion
CardioPhase was shown to raise coronary artery perfusion pressure,
increase blood supply to the myocardium, lower myocardial
consumption of oxygen, restore the rate of blood supply and
consumption by heart tissues, and improve the blood-pumping
function of the myocardium. These improvements in the blood-pumping
function of the myocardium may be related to improvements
in the biochemistry of heart muscle tissue metabolism.
CardioPhase was found to lower
leaf chamber spray blood resistance (VER), pulmonary arterial
pressure (PAP), total periphery resistance (TPR), etc. These
improvements in cardiac pump function may relate to positive
expansion of cardiac blood vessels.
CardioPhase can decrease whole
blood (WB) and reduced blood viscosity (RB), and improve microcirculation
to the cardiac muscle capillary system in patients with coronary
artery disease. |
